Dynamical DNA accessibility induced by chromatin remodeling and protein binding

Abstract : Chromatin remodeling factors are enzymes being able to alter locally chromatin structure at the nucleosomal level and they actively participate in the regulation of gene expression. Using simple rules for individual nucleosome motion induced by a remodeling factor, we designed simulations of the remodeling of oligomeric chromatin, in order to address quantitatively collective effects in DNA accessibility upon nucleosome mobilization. Our results suggest that accessibility profiles are inhomogeneous thanks to borders effects like protein binding. Remarkably, we show that the accessibility lifetime of DNA sequence is roughly doubled in the vicinity of borders as compared to its value in bulk regions far from the borders. These results are quantitatively interpreted as resulting from the confined diffusion of a large nucleosome depleted region.
Type de document :
Article dans une revue
Physical Review E : Statistical, Nonlinear, and Soft Matter Physics, American Physical Society, 2014, 90, pp.052717. 〈10.1103/PhysRevE.90.052717〉
Liste complète des métadonnées

Littérature citée [11 références]  Voir  Masquer  Télécharger

https://hal-ens-lyon.archives-ouvertes.fr/ensl-01084485
Contributeur : Martin Castelnovo <>
Soumis le : mardi 9 décembre 2014 - 22:02:16
Dernière modification le : jeudi 15 novembre 2018 - 20:26:53
Document(s) archivé(s) le : vendredi 14 avril 2017 - 20:22:33

Fichiers

manuscript31oct14.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

F Montel, Cendrine Faivre-Moskalenko, Martin Castelnovo. Dynamical DNA accessibility induced by chromatin remodeling and protein binding. Physical Review E : Statistical, Nonlinear, and Soft Matter Physics, American Physical Society, 2014, 90, pp.052717. 〈10.1103/PhysRevE.90.052717〉. 〈ensl-01084485〉

Partager

Métriques

Consultations de la notice

108

Téléchargements de fichiers

70