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Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

Abstract : The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well characterized in non-neuronal cells, a proliferation of papers over the past few years has revealed a key role for the UPR in normal neuronal function and as an important driver of neurodegenerative diseases. A complex scenario is emerging in which distinct UPR signalling modules have specific and even opposite effects on neurodegeneration depending on the disease context. Here, we provide an overview of the most recent findings addressing the biological relevance of ER stress in the nervous system.
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Contributor : Agnès Ganivet Connect in order to contact the contributor
Submitted on : Wednesday, October 15, 2014 - 9:35:30 AM
Last modification on : Wednesday, November 20, 2019 - 2:51:41 AM


  • HAL Id : ensl-01074636, version 1



Claudio Hetz, Bertrand Mollereau. Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases. Nature Reviews Neuroscience, Nature Publishing Group, 2014, 15, pp.233-249. ⟨ensl-01074636⟩



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