CST Meets Shelterin to Keep Telomeres in Check

Abstract : Telomere protection in budding yeast requires the heterotrimer named CST (for Cdc13-Stn1-Ten1). Recent data show that CST components are conserved and required for telomere stability in a wide range of eukaryotes, even those utilizing the shelterin complex to protect their telomeres. A common function of these proteins might be to stimulate priming at the C-strand gap that remains after telomerase elongation, replication termination, and terminal processing. In light of the budding yeast situation, another conserved function of CST might well be the regulation of telomerase. The cohabitation at telomeres of CST and shelterin components highlights the complexity of telomere biology.
Document type :
Journal articles
Complete list of metadatas

https://hal-ens-lyon.archives-ouvertes.fr/ensl-00815741
Contributor : Agnès Ganivet <>
Submitted on : Friday, April 19, 2013 - 12:11:36 PM
Last modification on : Thursday, February 7, 2019 - 5:09:40 PM

Identifiers

  • HAL Id : ensl-00815741, version 1
  • DOI : 10.1016

Citation

Marie-Josèphe Giraud-Panis, M. Teresa Teixeira, Vincent Géli, Eric Gilson. CST Meets Shelterin to Keep Telomeres in Check. Molecular Cell, Elsevier, 2010, 39 (5), pp.665-676. ⟨10.1016⟩. ⟨ensl-00815741⟩

Share

Metrics

Record views

117