Fatty Acid Desaturation Links Germ Cell Loss to Longevity Through NHR-80/HNF4 in C. elegans

Abstract : Reproduction and aging are two processes that seem to be closely intertwined. Experiments in Caenorhabditis elegans and Drosophila have shown that depletion of the germ line increases lifespan and that this process depends on insulin and lipophilic-hormone signaling. Recently, it was demonstrated that when germline stem cells (GSCs) cease to proliferate, fat metabolism is altered and this affects longevity. In this study, we have identified a nuclear hormone receptor, NHR-80, that mediates longevity through depletion of the germ line by promoting fatty acid desaturation. The nhr-80 gene is up-regulated at the mRNA and protein levels in germline-less animals, leading to the transcription of the gene, fat-6, and the production of oleic acid (OA). Our experiments also show that the NHR-80/FAT-6/OA pathway does not require the presence of DAF-16 but instead, depends fully on the presence of DAF-12, a steroid receptor that affects lifespan. We provide evidence that other NHR-80 targets must be present concomitantly. Our results reinforce the notion that fat metabolism is profoundly altered in response to GSC proliferation, and the data contribute to a better understanding of the molecular relationship between reproduction, fat metabolism, and aging.
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Article dans une revue
PLoS Biology, Public Library of Science, 2011, 9 (3), pp.e1000599. 〈10.1371〉
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Contributeur : Agnès Ganivet <>
Soumis le : lundi 8 avril 2013 - 16:24:53
Dernière modification le : jeudi 8 février 2018 - 11:09:30

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  • HAL Id : ensl-00809202, version 1
  • DOI : 10.1371

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Jérôme Goudeau, Stéphanie Bellemin, Esther Toselli-Mollereau, Mehrnaz Shamalnasab, Yiqun Chen, et al.. Fatty Acid Desaturation Links Germ Cell Loss to Longevity Through NHR-80/HNF4 in C. elegans. PLoS Biology, Public Library of Science, 2011, 9 (3), pp.e1000599. 〈10.1371〉. 〈ensl-00809202〉

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