Relevance of a scoring system including CD11c expression in the identification of splenic diffuse red pulp small B-cell lymphoma (SRPL)

Lucile Baseggio (1, 2) , Alexandra Traverse-Glehen (1, 3) , Evelyne Callet-Bauchu (1, 2) , Dominique Morel (1, 2) , Jean-Pierre Magaud (1, 2) , Françoise Berger (1, 3) , Gilles Salles (1, 4) , Pascale Felman (1, 2)

1 LBMC - Laboratoire de Biologie Moléculaire de la Cellule
2 Laboratoire d'Hématologie Cellulaire
3 Service d'Anatomie Pathologique
4 Service d'Hématologie clinique

'Splenic red pulp lymphoma with numerous basophilic villous lymphocytes' (SRPL), recently described, is characterized by clinical, morphologic, immunologic, cytogenetic and molecular features distinct from SMZL/SLVL and HCL. In particular, the intensity of CD11c staining (expressed as fluorescence intensity -RFI-) in SRPL is significantly different from the RFI in SMZL/SLVL and HCL. Moreover the use of a scoring system based on the expression of CD11c, CD22, CD76, CD38 and CD27 appears to improve the differential diagnosis between SRPL and SMZL/SLVL and emphasizes that SRPL is an entity closed to but distinct from SMZL/SLVL. Copyright © 2010 John Wiley & Sons, Ltd.

Keywords: CD11c; hairy-cell variant; immunophenotype; splenic lymphoma with villous lymphocytes; splenic marginal zone lymphoma; splenic red pulp lymphoma with numerous basophilic villous lymphocytes

Domains: Life Sciences [q-bio]; Human health and pathology; Hematology

Lucile Baseggio, Alexandra Traverse-Glehen, Evelyne Callet-Bauchu, Dominique Morel, Jean-Pierre Magaud, et al.. Relevance of a scoring system including CD11c expression in the identification of splenic diffuse red pulp small B-cell lymphoma (SRPL). Hematological Oncology, 2011, 29 (1), pp.47-51. ⟨ensl-00808949⟩