Relevance of a scoring system including CD11c expression in the identification of splenic diffuse red pulp small B-cell lymphoma (SRPL)

Abstract : 'Splenic red pulp lymphoma with numerous basophilic villous lymphocytes' (SRPL), recently described, is characterized by clinical, morphologic, immunologic, cytogenetic and molecular features distinct from SMZL/SLVL and HCL. In particular, the intensity of CD11c staining (expressed as fluorescence intensity -RFI-) in SRPL is significantly different from the RFI in SMZL/SLVL and HCL. Moreover the use of a scoring system based on the expression of CD11c, CD22, CD76, CD38 and CD27 appears to improve the differential diagnosis between SRPL and SMZL/SLVL and emphasizes that SRPL is an entity closed to but distinct from SMZL/SLVL. Copyright © 2010 John Wiley & Sons, Ltd.
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https://hal-ens-lyon.archives-ouvertes.fr/ensl-00808949
Contributor : Agnès Ganivet <>
Submitted on : Monday, April 8, 2013 - 11:37:02 AM
Last modification on : Thursday, February 7, 2019 - 4:22:43 PM

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  • HAL Id : ensl-00808949, version 1
  • DOI : 10.1002

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Lucile Baseggio, Alexandra Traverse-Glehen, Evelyne Callet-Bauchu, Dominique Morel, Jean-Pierre Magaud, et al.. Relevance of a scoring system including CD11c expression in the identification of splenic diffuse red pulp small B-cell lymphoma (SRPL). Hematological Oncology, Wiley, 2011, 29 (1), pp.47-51. ⟨10.1002⟩. ⟨ensl-00808949⟩

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