Drosophila Fatty Acid Transport Protein Regulates Rhodopsin-1 Metabolism and Is Required for Photoreceptor Neuron Survival

Pierre Dourlen 1 Benjamin Bertin 1 Gilles Chatelain 1 Marion Robin 1 Francesco Napoletano 1 Michel J Roux 2 Bertrand Mollereau 1
1 LBMC - Laboratoire de Biologie Moléculaire de la Cellule
2 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
Abstract : Tight regulation of the visual response is essential for photoreceptor function and survival. Visual response dysregulation often leads to photoreceptor cell degeneration, but the causes of such cell death are not well understood. In this study, we investigated a fatty acid transport protein (fatp) null mutation that caused adult-onset and progressive photoreceptor cell death. Consistent with fatp having a role in the retina, we showed that fatp is expressed in adult photoreceptors and accessory cells and that its re-expression in photoreceptors rescued photoreceptor viability in fatp mutants. The visual response in young fatp-mutant flies was abnormal with elevated electroretinogram amplitudes associated with high levels of Rhodopsin-1 (Rh1). Reducing Rh1 levels in rh1 mutants or depriving flies of vitamin A rescued photoreceptor cell death in fatp mutant flies. Our results indicate that fatp promotes photoreceptor survival by regulating Rh1 abundance.
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https://hal-ens-lyon.archives-ouvertes.fr/ensl-00807522
Contributor : Agnès Ganivet <>
Submitted on : Wednesday, April 3, 2013 - 4:57:24 PM
Last modification on : Friday, June 28, 2019 - 9:38:04 AM

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  • HAL Id : ensl-00807522, version 1
  • DOI : 10.1371

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ENS-LYON | IGBMC | UNIV-LYON1 | SITE-ALSACE

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Pierre Dourlen, Benjamin Bertin, Gilles Chatelain, Marion Robin, Francesco Napoletano, et al.. Drosophila Fatty Acid Transport Protein Regulates Rhodopsin-1 Metabolism and Is Required for Photoreceptor Neuron Survival. PLoS Genetics, Public Library of Science, 2012, 8 (7), pp.e1002833. ⟨10.1371⟩. ⟨ensl-00807522⟩

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