Entropic control of particle sizes during viral self-assembly

Abstract : Morphologic diversity is observed across all families of viruses. Yet these supra-molecular assemblies are produced most of the time in a spontaneous way through complex molecular self-assembly scenarios. The modeling of these phenomena remains a challenging problem within the emerging field of Physical Virology. We present in this work a theoretical analysis aiming at highlighting the particular role of configuration entropy in the control of viral particle size distribution. Specializing this model to retroviruses like HIV-1, we predict a new mechanism of entropic control of both RNA uptake into the viral particle, and of the particle's size distribution. Evidence of this peculiar behavior has been recently reported experimentally.
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https://hal-ens-lyon.archives-ouvertes.fr/ensl-00790070
Contributeur : Martin Castelnovo <>
Soumis le : mardi 19 février 2013 - 17:49:00
Dernière modification le : jeudi 19 avril 2018 - 14:54:04
Document(s) archivé(s) le : dimanche 2 avril 2017 - 02:36:22

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  • HAL Id : ensl-00790070, version 1
  • ARXIV : 1302.4724

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Martin Castelnovo, Delphine Muriaux, Cendrine Faivre-Moskalenko. Entropic control of particle sizes during viral self-assembly. 2013. 〈ensl-00790070〉

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