Skip to Main content Skip to Navigation
Preprints, Working Papers, ...

Entropic control of particle sizes during viral self-assembly

Abstract : Morphologic diversity is observed across all families of viruses. Yet these supra-molecular assemblies are produced most of the time in a spontaneous way through complex molecular self-assembly scenarios. The modeling of these phenomena remains a challenging problem within the emerging field of Physical Virology. We present in this work a theoretical analysis aiming at highlighting the particular role of configuration entropy in the control of viral particle size distribution. Specializing this model to retroviruses like HIV-1, we predict a new mechanism of entropic control of both RNA uptake into the viral particle, and of the particle's size distribution. Evidence of this peculiar behavior has been recently reported experimentally.
Complete list of metadatas

Cited literature [13 references]  Display  Hide  Download

https://hal-ens-lyon.archives-ouvertes.fr/ensl-00790070
Contributor : Martin Castelnovo <>
Submitted on : Tuesday, February 19, 2013 - 5:49:00 PM
Last modification on : Thursday, November 21, 2019 - 2:12:52 AM
Document(s) archivé(s) le : Sunday, April 2, 2017 - 2:36:22 AM

Files

manuscriptCASTELNOVO.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : ensl-00790070, version 1
  • ARXIV : 1302.4724

Collections

Citation

Martin Castelnovo, Delphine Muriaux, Cendrine Faivre-Moskalenko. Entropic control of particle sizes during viral self-assembly. 2013. ⟨ensl-00790070⟩

Share

Metrics

Record views

210

Files downloads

203