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Journal articles
Structural correlations and melting of B-DNA fibres
Abstract : Despite numerous attempts, the understanding of the thermal denaturation of DNA is still a challenge due to the lack of structural data at the transition since standard experimental approaches to DNA melting are made in solution and do not provide spatial information. We report a measurement using neutron scattering from oriented DNA fibres to determine the size of the regions that stay in the double-helix conformation as the melting temperature is approached from below. A Bragg peak from the B-form of DNA has been observed as a function of temperature and its width and integrated intensity have bean measured. These results, complemented by a differential calorimetry study of the melting of B DNA fibres as well as electrophoresis and optical observation data, are analysed in terms of a one-dimensional mesoscopic model of DNA.
Cited literature [22 references]
https://hal-ens-lyon.archives-ouvertes.fr/ensl-00600164
Contributor : Michel Peyrard Connect in order to contact the contributor
Submitted on : Tuesday, June 14, 2011 - 9:49:10 AM
Last modification on : Tuesday, October 19, 2021 - 10:50:45 PM
Long-term archiving on: : Sunday, December 4, 2016 - 11:28:36 PM
Contributor : Michel Peyrard Connect in order to contact the contributor
Submitted on : Tuesday, June 14, 2011 - 9:49:10 AM
Last modification on : Tuesday, October 19, 2021 - 10:50:45 PM
Long-term archiving on: : Sunday, December 4, 2016 - 11:28:36 PM
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