Multi-scale coding of genomic information: From DNA sequence to genome structure and function

Abstract : Understanding how chromatin is spatially and dynamically organized in the nucleus of eukaryotic cells and how this affects genome functions is one of the main challenges of cell biology. Since the different orders of packaging in the hierarchical organization of DNA condition the accessibility of DNA sequence elements to trans-acting factors that control the transcription and replication processes, there is actually a wealth of structural and dynamical information to learn in the primary DNA sequence. In this review, we show that when using concepts, methodologies, numerical and experimental techniques coming from statistical mechanics and nonlinear physics combined with wavelet-based multi-scale signal processing, we are able to decipher the multi-scale sequence encoding of chromatin condensation–decondensation mechanisms that play a fundamental role in regulating many molecular processes involved in nuclear functions.
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Physics Reports, Elsevier, 2011, pp.45-188. 〈10.1016/j.physrep.2010.10.001〉
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https://hal-ens-lyon.archives-ouvertes.fr/ensl-00572973
Contributeur : Benjamin Audit <>
Soumis le : mercredi 2 mars 2011 - 16:24:00
Dernière modification le : jeudi 19 avril 2018 - 14:54:03

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Alain Arnéodo, Cédric Vaillant, Benjamin Audit, Françoise Argoul, Yves D'Aubenton-Carafa, et al.. Multi-scale coding of genomic information: From DNA sequence to genome structure and function. Physics Reports, Elsevier, 2011, pp.45-188. 〈10.1016/j.physrep.2010.10.001〉. 〈ensl-00572973〉

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