The thermal denaturation of DNA studied with neutron scattering

Andrew Wildes 1 Nikos Theodorakopoulos 2, 3 Jessica Valle Orero 1, 4 Santiago Cuesta-Lopez 4 Jean-Luc Garden 5 Michel Peyrard 4
1 ILL - Institut Laue-Langevin
2 Theoretical and Physical Chemistry Institute NHRF
3 Fachbereich Physik [Konstanz]
4 Phys-ENS - Laboratoire de Physique de l'ENS Lyon
5 CapTher - Capteurs thermométriques et calorimétrie
NEEL - Institut Néel
Abstract : The melting transition of deoxyribonucleic acid (DNA), whereby the strands of the double helix structure completely separate at a certain temperature, has been characterized using neutron scattering. A Bragg peak from B-form fibre DNA has been measured as a function of temperature, and its widths and integrated intensities have been interpreted using the Peyrard-Bishop-Dauxois (PBD) model with only one free parameter. The experiment is unique, as it gives spatial correlation along the molecule through the melting transition where other techniques cannot.
keyword : DNA thermal denaturation neutron scattering
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Andrew Wildes, Nikos Theodorakopoulos, Jessica Valle Orero, Santiago Cuesta-Lopez, Jean-Luc Garden, et al.. The thermal denaturation of DNA studied with neutron scattering. Physical Review Letters, American Physical Society, 2011, 106 (4), pp.048101-1-4. ⟨10.1103/PhysRevLett.106.048101⟩. ⟨ensl-00554005⟩

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