The thermal denaturation of DNA studied with neutron scattering

Abstract : The melting transition of deoxyribonucleic acid (DNA), whereby the strands of the double helix structure completely separate at a certain temperature, has been characterized using neutron scattering. A Bragg peak from B-form fibre DNA has been measured as a function of temperature, and its widths and integrated intensities have been interpreted using the Peyrard-Bishop-Dauxois (PBD) model with only one free parameter. The experiment is unique, as it gives spatial correlation along the molecule through the melting transition where other techniques cannot.
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Andrew Wildes, Nikos Theodorakopoulos, Jessica Valle Orero, Santiago Cuesta-Lopez, Jean-Luc Garden, et al.. The thermal denaturation of DNA studied with neutron scattering. Physical Review Letters, American Physical Society, 2011, 106 (4), pp.048101-1-4. ⟨10.1103/PhysRevLett.106.048101⟩. ⟨ensl-00554005⟩

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