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Journal articles
Adding a New Dimension to DNA Melting Curves.
Abstract : Standard DNA melting curves record the separation of the two strands versus temperature, but they do not provide any information on the location of the opening. We introduce an experimental method which adds a new dimension to the melting curves of short DNA sequences by allowing us to record the degree of opening in several positions along the molecule all at once. This adds the spatial dimension to the melting curves and allows a precise investigation of the role of the base-pair sequence on the fluctuations and denaturation of the DNA double helix. We illustrate the power of the method by investigating the influence of an AT rich region on the fluctuations of neighboring domains.
Cited literature [14 references]
https://hal-ens-lyon.archives-ouvertes.fr/ensl-00410290
Contributor : Michel Peyrard Connect in order to contact the contributor
Submitted on : Wednesday, August 19, 2009 - 3:28:33 PM
Last modification on : Friday, February 12, 2021 - 10:58:05 AM
Long-term archiving on: : Thursday, June 30, 2011 - 11:46:23 AM
Contributor : Michel Peyrard Connect in order to contact the contributor
Submitted on : Wednesday, August 19, 2009 - 3:28:33 PM
Last modification on : Friday, February 12, 2021 - 10:58:05 AM
Long-term archiving on: : Thursday, June 30, 2011 - 11:46:23 AM
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EPL-DNA-vsF2.pdf
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