Skip to Main content Skip to Navigation
New interface
Journal articles

Adding a New Dimension to DNA Melting Curves.

Abstract : Standard DNA melting curves record the separation of the two strands versus temperature, but they do not provide any information on the location of the opening. We introduce an experimental method which adds a new dimension to the melting curves of short DNA sequences by allowing us to record the degree of opening in several positions along the molecule all at once. This adds the spatial dimension to the melting curves and allows a precise investigation of the role of the base-pair sequence on the fluctuations and denaturation of the DNA double helix. We illustrate the power of the method by investigating the influence of an AT rich region on the fluctuations of neighboring domains.
Complete list of metadata

Cited literature [14 references]  Display  Hide  Download
Contributor : Michel Peyrard Connect in order to contact the contributor
Submitted on : Wednesday, August 19, 2009 - 3:28:33 PM
Last modification on : Friday, February 12, 2021 - 10:58:05 AM
Long-term archiving on: : Thursday, June 30, 2011 - 11:46:23 AM


Files produced by the author(s)




Santiago Cuesta-Lopez, Dimitar Angelov, Michel Peyrard. Adding a New Dimension to DNA Melting Curves.. EPL - Europhysics Letters, 2009, 87 (4), pp.48009-1-6. ⟨10.1209/0295-5075/87/48009⟩. ⟨ensl-00410290⟩



Record views


Files downloads