Discrete breathers in nonlinear network models of proteins

Brice Juanico 1 Yves-Henri Sanejouand 1 Francesco Piazza 2 Paolo de Los Rios 2
1 Phys-ENS - Laboratoire de Physique de l'ENS Lyon
2 Laboratoire de Biophysique Statistique-ITP
Abstract : We introduce a topology-based nonlinear network model of protein dynamics with the aim of investigating the interplay of spatial disorder and nonlinearity. We show that spontaneous localization of energy occurs generically and is a site-dependent process. Localized modes of nonlinear origin form spontaneously in the stiffest parts of the structure and display site-dependent activation energies. Our results provide a straightforward way for understanding the recently discovered link between protein local stiffness and enzymatic activity. They strongly suggest that nonlinear phenomena may play an important role in enzyme function, allowing for energy storage during the catalytic process.
Keywords : Normal Mode Analysis Nonlinearity Elastic Network Models Discrete Breathers
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Journal articles
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https://hal-ens-lyon.archives-ouvertes.fr/ensl-00200909
Contributor : Yves-Henri Sanejouand <>
Submitted on : Friday, December 21, 2007 - 7:57:34 PM
Last modification on : Thursday, November 21, 2019 - 2:34:03 AM

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Brice Juanico, Yves-Henri Sanejouand, Francesco Piazza, Paolo de Los Rios. Discrete breathers in nonlinear network models of proteins. Physical Review Letters, American Physical Society, 2007, 99, pp.238104. ⟨10.1103/PhysRevLett.99.238104⟩. ⟨ensl-00200909⟩

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