A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development

Abstract : Proteins of the highly conserved heterochromatin protein 1 (HP1) family have been found to function in the dynamic organization of nuclear architecture and in gene regulation throughout the eukaryotic kingdom. In addition to being key players in heterochromatin-mediated gene silencing, HP1 proteins may also contribute to the transcriptional repression of euchromatic genes via the recruitment to specific promoters. To investigate the role played by these different activities in specific developmental pathways, we identified HP1 homologues in the genome of Caenorhabditis elegans and used RNA-mediated interference to study their function. We show that one of the homologues, HPL-2, is required for the formation of a functional germline and for the development of the vulva by acting in an Rb-related pathway. We suggest that, by acting as repressors of gene expression, HP1 proteins may fulfil specific functions in both somatic and germline differentiation processes throughout development.
Type de document :
Article dans une revue
EMBO Reports, EMBO Press, 2002, pp.235-241
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Contributeur : Francesca Palladino <>
Soumis le : vendredi 26 octobre 2007 - 11:33:28
Dernière modification le : samedi 5 mai 2018 - 01:23:40
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  • HAL Id : ensl-00182503, version 1



Florence Couteau, Fréderic Guerry, Francesca Palladino, Fritz Muller. A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development. EMBO Reports, EMBO Press, 2002, pp.235-241. 〈ensl-00182503〉



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