M. Abrink, J. A. Ortiz, C. Mark, C. Sanchez, C. Looman et al., Conserved interaction between distinct Kruppel-associated box domains and the transcriptional intermediary factor 1 beta, Proceedings of the National Academy of Sciences, vol.98, issue.4, pp.1422-1426, 2001.
DOI : 10.1073/pnas.041616998

R. C. Allshire, E. R. Nimmo, K. Ekwall, J. P. Javerzat, and G. Cranston, Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation., Genes & Development, vol.9, issue.2, pp.218-233, 1995.
DOI : 10.1101/gad.9.2.218

R. V. Aroian, M. Koga, J. E. Mendel, Y. Ohshima, and P. W. Sternberg, The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily, Nature, vol.348, issue.6303, pp.693-699, 1990.
DOI : 10.1038/348693a0

N. Ayoub, I. Goldshmidt, and A. Cohen, Position effect variegation at the mating-type locus of fission yeast: a cis-acting element inhibits covariegated expression of genes in the silent and expressed domains, Genetics, vol.152, pp.495-508, 1999.

K. Ayyanathan, M. S. Lechner, P. Bell, G. G. Maul, D. C. Schultz et al., Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation, Genes & Development, vol.17, issue.15, pp.1855-1869, 2003.
DOI : 10.1101/gad.1102803

A. J. Bannister, P. Zegerman, J. F. Partridge, E. A. Miska, J. O. Thomas et al., Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain, Nature, vol.410, issue.6824, pp.120-124, 2001.
DOI : 10.1038/35065138

G. J. Beitel, S. G. Clark, and H. R. Horvitz, Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction, Nature, vol.348, issue.6301, pp.503-509, 1990.
DOI : 10.1038/348503a0

S. V. Brasher, B. O. Smith, R. H. Fogh, D. Nietlispach, A. Thiru et al., The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer, The EMBO Journal, vol.19, issue.7, pp.1587-1597, 2000.
DOI : 10.1093/emboj/19.7.1587

S. Brenner, The genetics of Caenorhabditis elegans, Genetics, vol.77, pp.71-94, 1974.

F. Cammas, M. Herzog, T. Lerouge, P. Chambon, and R. Losson, Association of the transcriptional corepressor TIF1?? with heterochromatin protein 1 (HP1): an essential role for progression through differentiation, Genes & Development, vol.18, issue.17, pp.2147-2160, 2004.
DOI : 10.1101/gad.302904

C. J. Ceol and R. H. Horvitz, dpl-1 DP and efl-1 E2F Act with lin-35 Rb to Antagonize Ras Signaling in C. elegans Vulval Development, Molecular Cell, vol.7, issue.3, pp.461-473, 2001.
DOI : 10.1016/S1097-2765(01)00194-0

C. J. Ceol and H. R. Horvitz, A New Class of C. elegans synMuv Genes Implicates a Tip60/NuA4-like HAT Complex as a Negative Regulator of Ras Signaling, Developmental Cell, vol.6, issue.4, pp.563-576, 2004.
DOI : 10.1016/S1534-5807(04)00065-6

N. Chen and I. Greenwald, The Lateral Signal for LIN-12/Notch in C. elegans Vulval Development Comprises Redundant Secreted and Transmembrane DSL Proteins, Developmental Cell, vol.6, issue.2, pp.183-192, 2004.
DOI : 10.1016/S1534-5807(04)00021-8

Z. Chen and M. Han, C. elegans Rb, NuRD, and Ras regulate lin-39-mediated cell fusion during vulval fate specification, Current Biology, vol.11, issue.23, pp.1874-1879, 2001.
DOI : 10.1016/S0960-9822(01)00596-6

URL : https://hal.archives-ouvertes.fr/in2p3-00115430

F. Couteau, F. Guerry, F. Muller, and F. Palladino, A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development, EMBO Reports, vol.3, issue.3, pp.235-241, 2002.
DOI : 10.1093/embo-reports/kvf051

URL : https://hal.archives-ouvertes.fr/ensl-00182503

I. G. Cowell, R. Aucott, S. K. Mahadevaiah, P. S. Burgoyne, N. Huskisson et al., Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals, HP1 and methylation at lysine 9 of histone H3 in animals, pp.22-36, 2002.
DOI : 10.1007/s00412-002-0182-8

P. Dufourcq, M. Victor, F. Gay, D. Calvo, J. Hodgkin et al., Functional Requirement for Histone Deacetylase 1 in Caenorhabditis elegans Gonadogenesis, Molecular and Cellular Biology, vol.22, issue.9, pp.3024-3034, 2002.
DOI : 10.1128/MCB.22.9.3024-3034.2002

T. Durfee, K. Becherer, P. L. Chen, S. H. Yeh, Y. Yang et al., The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit., Genes & Development, vol.7, issue.4, pp.555-569, 1993.
DOI : 10.1101/gad.7.4.555

J. C. Eissenberg, Molecular biology of the chromo domain: an ancient chromatin module comes of age, Gene, vol.275, issue.1, pp.19-29, 2001.
DOI : 10.1016/S0378-1119(01)00628-X

J. C. Eissenberg and S. C. Elgin, The HP1 protein family: getting a grip on chromatin, Current Opinion in Genetics & Development, vol.10, issue.2, pp.204-210, 2000.
DOI : 10.1016/S0959-437X(00)00058-7

S. J. Elledge, J. T. Mulligan, S. W. Ramer, M. Spottswood, and R. W. Davis, Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations., Proceedings of the National Academy of Sciences, vol.88, issue.5, pp.1731-1735, 1991.
DOI : 10.1073/pnas.88.5.1731

E. L. Ferguson and H. R. Horvitz, The multivulva phenotype of certain V. Coustham et al, Developmental Biology, vol.297, pp.308-322, 1989.

C. G. Fink, Guide to yeast genetics and molecular biology, Methods Enzymol, vol.194, pp.3-21, 1991.

A. Fire, S. Xu, M. K. Montgomery, S. A. Kostas, S. E. Driver et al., Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans (see comments, Nature, vol.391, issue.6669, pp.806-811, 1998.
DOI : 10.1038/35888

M. Fromont-racine, J. C. Rain, and P. Legrain, Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens, Nature Genetics, vol.88, issue.3, pp.277-282, 1997.
DOI : 10.1016/0378-1119(96)00230-2

I. Greenwald and G. Seydoux, Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans, Nature, vol.346, issue.6280, pp.197-199, 1990.
DOI : 10.1038/346197a0

I. S. Greenwald, P. W. Sternberg, and H. R. Horvitz, The lin-12 locus specifies cell fates in caenorhabditis elegans, Cell, vol.34, issue.2, pp.435-444, 1983.
DOI : 10.1016/0092-8674(83)90377-X

F. Greil, I. Van-der-kraan, J. Delrow, J. F. Smothers, E. De-wit et al., Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location, Genes & Development, vol.17, issue.22, pp.2825-2838, 2003.
DOI : 10.1101/gad.281503

S. T. Henderson, D. Gao, S. Christensen, and J. Kimble, Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans., Molecular Biology of the Cell, vol.8, issue.9, pp.1751-1762, 1997.
DOI : 10.1091/mbc.8.9.1751

S. A. Jacobs, S. D. Taverna, Y. Zhang, S. D. Briggs, J. Li et al., Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3, The EMBO Journal, vol.20, issue.18, pp.5232-5241, 2001.
DOI : 10.1093/emboj/20.18.5232

R. S. Kamath and J. Ahringer, Genome-wide RNAi screening in Caenorhabditis elegans, Methods, vol.30, issue.4, pp.313-321, 2003.
DOI : 10.1016/S1046-2023(03)00050-1

M. Korenjak, B. Taylor-harding, U. K. Binne, J. S. Satterlee, O. Stevaux et al., Native E2F/RBF Complexes Contain Myb-Interacting Proteins and Repress Transcription of Developmentally Controlled E2F Target Genes, Cell, vol.119, issue.2, pp.181-193, 2004.
DOI : 10.1016/j.cell.2004.09.034

M. Lachner, D. O-'carroll, S. Rea, K. Mechtler, and T. Jenuwein, Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins, Nature, vol.410, issue.6824, pp.116-120, 2001.
DOI : 10.1038/35065132

M. S. Lechner, G. E. Begg, D. W. Speicher, I. Rauscher, and F. J. , Molecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain-KAP-1 Corepressor Interaction Is Essential, Molecular and Cellular Biology, vol.20, issue.17, pp.6449-6465, 2000.
DOI : 10.1128/MCB.20.17.6449-6465.2000

M. S. Lechner, D. C. Schultz, D. Negorev, G. G. Maul, I. Rauscher et al., The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain, Biochemical and Biophysical Research Communications, vol.331, issue.4, pp.929-937, 2005.
DOI : 10.1016/j.bbrc.2005.04.016

L. Douarin, B. Nielsen, A. L. Garnier, J. M. Ichinose, H. Jeanmougin et al., A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors, EMBO J, vol.15, pp.6701-6715, 1996.

P. W. Lewis, E. L. Beall, T. C. Fleischer, D. Georlette, A. J. Link et al., Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex, Genes & Development, vol.18, issue.23, pp.2929-2940, 2004.
DOI : 10.1101/gad.1255204

Y. Li, D. A. Kirschmann, and L. L. Wallrath, Does heterochromatin protein 1 always follow code?, Proceedings of the National Academy of Sciences, vol.99, issue.Supplement 4, pp.16462-16469, 2002.
DOI : 10.1073/pnas.162371699

Y. Li, J. R. Danzer, P. Alvarez, A. S. Belmont, and L. L. Wallrath, Effects of tethering HP1 to euchromatic regions of the Drosophila genome, Development, vol.130, issue.9, pp.1817-1824, 2003.
DOI : 10.1242/dev.00405

B. Linder, N. Gerlach, and H. Jackle, The Drosophila homolog of the human AF10 is an HP1-interacting suppressor of position effect variegation, EMBO reports, vol.2, issue.10, pp.211-216, 2001.
DOI : 10.1038/sj.embor.7400271

X. Lu and H. R. Horvitz, lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48, Cell, vol.95, issue.7, pp.981-991, 1998.
DOI : 10.1016/S0092-8674(00)81722-5

P. E. Mains and J. D. Mcghee, C elegans: a practical approach, 1999.

A. Melendez and I. Greenwald, Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif, Genetics, vol.155, pp.1127-1137, 2000.

C. C. Mello, J. M. Kramer, D. Stinchcomb, and V. Ambros, Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences, EMBO J, vol.10, pp.3959-3970, 1991.

N. Murzina, A. Verreault, E. Laue, and B. Stillman, Heterochromatin Dynamics in Mouse Cells, Molecular Cell, vol.4, issue.4, pp.529-540, 1999.
DOI : 10.1016/S1097-2765(00)80204-X

T. R. Myers and I. Greenwald, lin-35 Rb Acts in the Major Hypodermis to Oppose Ras-Mediated Vulval Induction in C. elegans, Developmental Cell, vol.8, issue.1, pp.117-123, 2005.
DOI : 10.1016/j.devcel.2004.11.015

J. Nakayama, J. C. Rice, B. D. Strahl, C. D. Allis, and S. I. Grewal, Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly, Science, vol.292, issue.5514, pp.110-113, 2001.
DOI : 10.1126/science.1060118

S. J. Nielsen, R. Schneider, U. M. Bauer, A. J. Bannister, A. Morrison et al., Rb targets histone H3 methylation and HP1 to promoters, Nature, vol.197, issue.6846, pp.561-565, 2001.
DOI : 10.1038/35087620

P. R. Nielsen, D. Nietlispach, H. R. Mott, J. Callaghan, A. Bannister et al., Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9, Nature, vol.6, issue.6876, pp.103-107, 2002.
DOI : 10.1038/nature722

H. Ogawa, K. Ishiguro, S. Gaubatz, D. M. Livingston, and Y. Nakatani, A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G0 Cells, Science, vol.296, issue.5570, pp.1132-1136, 2002.
DOI : 10.1126/science.1069861

H. Peng, G. E. Begg, D. C. Schultz, J. R. Friedman, D. E. Jensen et al., Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions, Journal of Molecular Biology, vol.295, issue.5, pp.1139-1162, 2000.
DOI : 10.1006/jmbi.1999.3402

G. Poulin, Y. Dong, A. G. Fraser, N. A. Hopper, and J. Ahringer, Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans, The EMBO Journal, vol.36, issue.14, pp.2613-2623, 2005.
DOI : 10.1038/sj.emboj.7600726

J. M. Ross and D. Zarkower, Polycomb Group Regulation of Hox Gene Expression in C. elegans, Developmental Cell, vol.4, issue.6, pp.891-901, 2003.
DOI : 10.1016/S1534-5807(03)00135-7

D. C. Schultz, K. Ayyanathan, D. Negorev, G. G. Maul, I. Rauscher et al., SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins, Genes & Development, vol.16, issue.8, pp.919-932, 2002.
DOI : 10.1101/gad.973302

F. Solari and J. Ahringer, NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans, Current Biology, vol.10, issue.4, pp.223-226, 2000.
DOI : 10.1016/S0960-9822(00)00343-2

J. B. Spofford, Position Effect Variegation in Drosophila, 1976.

P. W. Sternberg, Lateral inhibition during vulval induction in Caenorhabditis elegans, Nature, vol.335, issue.6190, pp.551-554, 1988.
DOI : 10.1038/335551a0

J. E. Sulston and H. R. Horvitz, Post-embryonic cell lineages of the nematode, Caenorhabditis elegans, Developmental Biology, vol.56, issue.1, pp.110-156, 1977.
DOI : 10.1016/0012-1606(77)90158-0

A. Thiru, D. Nietlispach, H. R. Mott, M. Okuwaki, D. Lyon et al., Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin, The EMBO Journal, vol.23, issue.3, pp.489-499, 2004.
DOI : 10.1038/sj.emboj.7600088

J. H. Thomas, C. J. Ceol, H. T. Schwartz, and H. R. Horvitz, New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans, Genetics, vol.164, pp.135-151, 2003.

M. F. Vassallo and N. Tanese, Isoform-specific interaction of HP1 with human TAFII130, Proceedings of the National Academy of Sciences, vol.99, issue.9, pp.5919-5924, 2002.
DOI : 10.1073/pnas.092025499

T. Von-zelewsky, F. Palladino, K. Brunschwig, H. Tobler, A. Hajnal et al., The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination, Process Citation) Development, pp.5277-5284, 2000.
URL : https://hal.archives-ouvertes.fr/hal-00023801

D. Wang, S. Kennedy, C. Jr, D. Kim, J. K. Gabel et al., Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants, Nature, vol.63, issue.7050, pp.593-597, 2005.
DOI : 10.1126/science.1072530