Dynamics of Bio-Polymeric Brushes Growing from a Cellular Membrane: Tentative Modelling of the Actin Turnover within an Adhesion Unit; the Podosome

Abstract : Podosomes are involved in the adhesion process of various cells to a solid substrate. They have been proven to consist of a dense actin core surrounded by an actin cloud. The podosomes, which nucleate when the cell comes in the vicinity of a substrate, contribute to link the membrane to the solid surface, but rather than frozen links, collective dynamical behaviors are experimentally observed. Depending on the differentiation stage, podosomes assemble and form clusters, rings or belts. Considering the dynamics of a polymeric brush, we design a simple model aiming at the description of a single podosome, the basic unit of these complex adhesion-structures and compare our theoretical conclusions to recent experimental results. Particularly, we explain, by solving the diffusion problem around the podosome, why the structure is likely to have a finite life-span.
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https://hal-ens-lyon.archives-ouvertes.fr/ensl-00178770
Contributeur : Jean-Christophe Géminard <>
Soumis le : vendredi 12 octobre 2007 - 10:40:07
Dernière modification le : mardi 11 septembre 2018 - 11:00:02
Document(s) archivé(s) le : dimanche 11 avril 2010 - 22:51:54

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  • HAL Id : ensl-00178770, version 1

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Thierry Biben, Jean-Christophe Géminard, Francisco Melo. Dynamics of Bio-Polymeric Brushes Growing from a Cellular Membrane: Tentative Modelling of the Actin Turnover within an Adhesion Unit; the Podosome. 2007. 〈ensl-00178770〉

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