From DNA sequence analysis to modeling replication in the human genome. - Archive ouverte HAL Access content directly
Journal Articles Physical Review Letters Year : 2005

From DNA sequence analysis to modeling replication in the human genome.

(1, 2) , (1, 2) , (3) , (1, 2) , (3) , (3) , (1, 2)
1
2
3

Abstract

We explore the large-scale behavior of nucleotide compositional strand asymmetries along human chromosomes. As we observe for 7 of 9 origins of replication experimentally identified so far, the (TA+GC) skew displays rather sharp upward jumps, with a linear decreasing profile in between two successive jumps. We present a model of replication with well positioned replication origins and random terminations that accounts for the observed characteristic serrated skew profiles. We succeed in identifying 287 pairs of putative adjacent replication origins with an origin spacing approximately 1-2 Mbp that are likely to correspond to replication foci observed in interphase nuclei and recognized as stable structures that persist throughout subsequent cell generations.
Fichier principal
Vignette du fichier
brodie_etal_manuscript.pdf (648.76 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

ensl-00175517 , version 1 (19-10-2007)

Identifiers

Cite

Edward-Benedict Brodie of Brodie, Samuel Nicolay, Marie Touchon, Benjamin Audit, Yves d'Aubenton-Carafa, et al.. From DNA sequence analysis to modeling replication in the human genome.. Physical Review Letters, 2005, 24 (94), pp.248103. ⟨ensl-00175517⟩
82 View
118 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More